Plateforme de chronobiologie

Cette activité s’articule autour de deux axes : étudier les possibilités de synchronisation des rythmes circadiens chez les patients glaucomateux et étudier les variations nycthémérales et circadiennes de la pression intraoculaire chez le patient glaucomateux et le patient atteint de syndrome d’apnées du sommeil.

Nous disposons également d’une expertise dans le domaine de l’évaluation des traitements pharmacologiques (traitements anti-glaucomateux, traitements agissant sur le flux sanguin oculaire, etc.) sur 24 heures (chronothérapeutique).

Publications récentes dans la thématique de la pression intra-oculaire :

Aptel F, Weinreb RN, Chiquet C, Mansouri K. 24-h monitoring devices and nyctohemeral rhythms of intraocular pressure. Prog Retin Eye Res. 2016.


Aptel F, Canaud P, Tamisier R, pépin JL, Mottet B, Hubanova R, Romanet JP, Chiquet C. Relationship between nocturnal intraocular pressure variations and sleep macrostructure. Invest Ophthalmol Vis Sci. 2015; 56: 15-17456


Hubanova R, Aptel F, Zhou T, Arnol N, Romanet JP, Chiquet C. Comparison of IOP measurements with the Reichert PT 100 , the Keeler Pulsair Intellipuff portable non-contact tonometers and Goldmann applanation tonometry. J Glaucoma 2015 24: 356-363


Aptel F, Tamisier R, Pépin JL, Mottet B, Hubanova R, Romanet JP, Chiquet C.  Hourly awakening versus continuous contact lens sensor measurements of 24-hour intraocular pressure: Impact on sleep macrostructure and intraocular pressure rhythm. JAMA Ophthalmology 2014 Oct;132(10):1232-8


Aptel F, Lesoin A, Chiquet C, MD, Aryal-Charles N, Noel C, Romanet JP. Long-term repeatability of diurnal intraocular pressure patterns in patients with glaucoma. Ophthalmology 2014 Oct;121(10):1998-2003


Mottet B, Aptel F, Romanet JP, Hubanova R, Pepin JL, Chiquet C. 24-Hour Intraocular Pressure Rhythm in young healthy subjects evaluated with Continuous Monitoring using Contact Lens Sensor. JAMA Ophthalmology 2013; 131(12):1507-16.


Hubanova R, Aptel F, Chiquet C, Mottet B, Romanet JP. Effect on corneal thickness of the triggerfish® sensor during overnight wear measured by Visante® anterior segment optical coherence tomography. Acta Ophthalmol 2013 Jul 15. doi: 10.1111/aos.12241


Aptel F, Chiquet C, Romanet JP. Intraocular Pressure-Lowering Combination Therapies with Prostaglandin Analogues: A Review. Drugs. 2012 Jul 9;72(10):1355-71.


Mottet B, Chiquet C, Aptel F, Buguet A, Noel C, Romanet JP. 24-hour intraocular pressure of healthy humans in supine position: rhythm and reproducibility. IOVS 2012 ; 53(13):8186-91


Pépin JL, Chiquet C, Tamisier R, Lévy P, Almanjoumi A, Romanet JP. Frequent loss of nyctohemeral rhythm of intraocular pressure restored by nCPAP treatment in patients with severe apnea. Arch Ophthalmol. 2010 Oct;128(10):1257-63.


Castejon H, Chiquet C, Savy O, Baguet JP, Khayi H, Tamisier R, Bourdon L, Romanet JP. Effect of acute increase in blood pressure on intraocular pressure in pigs and humans. Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1599-605.


Renard E, Palombi K, Gronfier C, Pepin JL, Noel C, Chiquet C, Romanet JP. Twenty-four hour (Nyctohemeral) rhythm of intraocular pressure and ocular perfusion pressure in normal-tension glaucoma. Invest Ophthalmol Vis Sci. 2010 Feb;51(2):882-9.